منابع مشابه
Channelling Evolution
Individuals within a wild population show remarkably little morphological variation, given the amount of environmental variation they encounter during development and the amount of genetic variation within the population. This phenotypic constancy led to the proposal that individuals were somehow buffered, or canalized, against genetic and environmental variation (Waddington 1942). Clearly, suc...
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Very little is known about how animal colour patterns develop. The stripes of the zebrafish provide a tractable a model for colour pattern formation, which now suggests an unconventional patterning mechanism.
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Stoicheiometric analysis of metabolic pathways provides a systematic way of determining which metabolite concentrations are subject to constraints, information that may otherwise be very difficult to recognize in a large branched pathway. The procedure involves representing the pathway structure in the form of a matrix and then carrying out row operations to convert the matrix into 'row echelon...
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We perform an extensive study of several different models of permutation problems proposed by Smith in [Smith, 2000]. We first define a measure of constraint tightness parameterized by the level of local consistency being enforced. We then compare the constraint tightness in these different models with respect to a large number of local consistency properties including arc-consistency, (restric...
متن کاملMetabolite Channelling and Metabolic Complexity Substrate channelling in 2-0x0 acid dehydrogenase multienzyme complexes
Heteronuclear NMR spectroscopy and other experiments indicate that the true substrate of the E l component of 2-0x0 acid dehydrogenase complexes is not lipoic acid but the lipoyl domain of the E2 component. E l can recognize the lipoyllysine residue as such, but reductive acylation ensues only if the domain to which the lipoyl group is attached is additionally recognized by virtue of a mosaic o...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2003
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm1164